发明公开
- 专利标题： PREPARATION OF PET PRECURSOR
- 专利标题（中）： PET前体的制备
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申请号： EP11801996.7申请日： 2011-11-28
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公开(公告)号： EP2646411A1公开(公告)日： 2013-10-09
- 发明人: BERG, Tom, Christian , NILSEN, Anne
- 申请人： GE Healthcare Limited
- 申请人地址： Amersham Place Little Chalfont Buckinghamshire HP7 9NA GB
- 专利权人： GE Healthcare Limited
- 当前专利权人： GE Healthcare Limited
- 当前专利权人地址： Amersham Place Little Chalfont Buckinghamshire HP7 9NA GB
- 代理机构： Bannan, Sally
- 优先权： US417490P 20101129
- 国际公布： WO2012072567 20120607
- 主分类号： C07C227/40
- IPC分类号： C07C227/40 ; C07C309/65 ; C07B59/00 ; C07C229/48 ; C07C269/08 ; C07C271/24
摘要：
The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabeled amino acids for use in
in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor of the [
18 F]-1-amino-3- fluorocyclobutanecarboxylic acid ([
18 F] FACBC) PET agent and particularly to the work-up process of this precursor removing generated salts from the intermediate composition.
in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor of the [
18 F]-1-amino-3- fluorocyclobutanecarboxylic acid ([
18 F] FACBC) PET agent and particularly to the work-up process of this precursor removing generated salts from the intermediate composition.
公开/授权文献
- EP2646411B1 PREPARATION OF PET PRECURSOR 公开/授权日：2017-08-16
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