发明公开
EP2646442A1 A NEW METHOD FOR PRODUCING ANTIFOLATE AGENTS HAVING GLUTAMIC ACID PART IN THEIR STRUCTURE
有权
PRODUCING抗叶酸剂含谷氨酸部结构的一种新方法
- 专利标题： A NEW METHOD FOR PRODUCING ANTIFOLATE AGENTS HAVING GLUTAMIC ACID PART IN THEIR STRUCTURE
- 专利标题（中）： PRODUCING抗叶酸剂含谷氨酸部结构的一种新方法
-
申请号： EP10807503.7申请日： 2010-12-03
-
公开(公告)号： EP2646442A1公开(公告)日： 2013-10-09
- 发明人: KOCAK, Ender , ASLAN, Tuncer
- 申请人： Kocak Farma Ilac Ve Kimya San. A.S
- 申请人地址： Baglarbasi Gazi Cad. No: 40 Uskudar 34664 Istanbul TR
- 专利权人： Kocak Farma Ilac Ve Kimya San. A.S
- 当前专利权人： Kocak Farma Ilac Ve Kimya San. A.S
- 当前专利权人地址： Baglarbasi Gazi Cad. No: 40 Uskudar 34664 Istanbul TR
- 代理机构： Lösch, Christoph Ludwig Klaus
- 国际公布： WO2012074496 20120607
- 主分类号： C07D475/08
- IPC分类号： C07D475/08
摘要：
A new method for producing antifolate agents having glutamic acid part in their structure is developed by protecting carboxyl groups of glutamic acid or its N-subsituted derivatives as cyanomethyl ester to give compounds of formula (II) which are hydrolyzed under very mild conditions to afford antifolate agents in high yield with high analytical and optical purity.
公开/授权文献
信息查询
