发明授权
EP2646473B1 FUSION PEPTIDE COMPRISING DHFAS-1 DOMAIN AND MMP SUBSTRATE AND USE THEREOF FOR PREVENTING AND TREATING RHEUMATOID ARTHRITIS
有权
与用于预防和治疗风湿性关节炎甲DHFAS-1结构域和MMP-SUBSTRATE及其用途融合肽
- 专利标题： FUSION PEPTIDE COMPRISING DHFAS-1 DOMAIN AND MMP SUBSTRATE AND USE THEREOF FOR PREVENTING AND TREATING RHEUMATOID ARTHRITIS
- 专利标题（中）： 与用于预防和治疗风湿性关节炎甲DHFAS-1结构域和MMP-SUBSTRATE及其用途融合肽
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申请号： EP11845862.9申请日： 2011-12-02
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公开(公告)号： EP2646473B1公开(公告)日： 2017-02-15
- 发明人: KANG, Young Mo , KIM, In San , KANG, Jin Hee , SA, Keum Hee
- 申请人： Kyungpook National University Industry- Academic Cooperation Foundation
- 申请人地址： Kyungpook National University 1370 Sangyeok-dong Buk-gu Daegu 702-701 KR
- 专利权人： Kyungpook National University Industry- Academic Cooperation Foundation
- 当前专利权人： Kyungpook National University Industry- Academic Cooperation Foundation
- 当前专利权人地址： Kyungpook National University 1370 Sangyeok-dong Buk-gu Daegu 702-701 KR
- 代理机构： Hoefer & Partner Patentanwälte mbB
- 优先权： KR20100121894 20101202
- 国际公布： WO2012074330 20120607
- 主分类号： C07K19/00
- IPC分类号： C07K19/00 ; C12N15/62 ; A61K38/17 ; A61P19/02
摘要：
The present invention relates to a fusion peptide comprising dhFas-1 domain and MMP substrate and use thereof. More specifically, the present invention relates to a fusion peptide, comprising a) a dhFas-1 domain which is the fourth fas-1 domain of βig-h3 lacking H1 and H2 regions; b) a MMP (Matrix metalloproteinase) substrate; and c) a peptide comprising RGD motif and an use thereof for preventing and treating inflammatory disease. The fusion peptide of the present invention inhibits expension of rheumatoid arthritis by adhesion and migration of sinoviocytes and may be used for preventing or treating inflammatory disease by inhibiting infiltration of immune cells.
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