- 专利标题： SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF
-
申请号： EP11850773申请日： 2011-12-21
-
公开(公告)号： EP2655388A4公开(公告)日： 2014-06-18
- 发明人: KAUL RAMESH , MCEACHERN ERNEST J , MU CHANGWEI , SELNICK HAROLD G , VOCADLO DAVID J , WANG YAODE , WEI ZHONGYONG , ZHOU YUANXI , ZHU YONGBAO
- 申请人： ALECTOS THERAPEUTICS INC , MERCK SHARP & DOHME
- 专利权人： ALECTOS THERAPEUTICS INC,MERCK SHARP & DOHME
- 当前专利权人： ALECTOS THERAPEUTICS INC,MERCK SHARP & DOHME
- 优先权： US201061426773 2010-12-23; CN2011074569 2011-05-24; US201161507684 2011-07-14
- 主分类号： C07H9/06
- IPC分类号： C07H9/06 ; A61K31/7056 ; C07D513/04 ; C12Q1/34
摘要：
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
信息查询
