发明授权
- 专利标题: TEST KIT FOR PLASMA OR SERUM ANTIBODY TITER AGAINST PERIODONTAL DISEASE-CAUSING BACTERIA
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申请号: EP11848325.4申请日: 2011-10-18
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公开(公告)号: EP2657703B1公开(公告)日: 2018-12-05
- 发明人: NOZOE, Mikio
- 申请人: Sunstar Inc.
- 申请人地址: 3-1 Asahi-machi Takatsuki-shi Osaka 569-1195 JP
- 专利权人: Sunstar Inc.
- 当前专利权人: Sunstar Inc.
- 当前专利权人地址: 3-1 Asahi-machi Takatsuki-shi Osaka 569-1195 JP
- 代理机构: Keirstead, Tanis Evelyne
- 优先权: JP2010279268 20101215
- 国际公布: WO2012081306 20120621
- 主分类号: G01N33/569
- IPC分类号: G01N33/569 ; C07K14/195 ; C12N15/09 ; G01N33/53 ; G01N33/543 ; G01N33/68
摘要:
The object of the present invention is to provide: a test kit for an antibody titer or an antibody against a periodontal disease-causing bacterium in a blood sample, which enables the testing on a periodontal disease in patients having a wide scope of immunotypes with high accuracy and can be treated by an automated device at a high speed; a periodontal disease-causing bacterium antigen protein which can be suitably used in the kit; a method for testing an antibody titer or the presence of an antibody in a blood sample using the kit; and a kit for typing strains of Porphyromonas gingivalis. The present invention discloses: a test kit comprising a set of polypeptides respectively having the acid sequences represented by SEQ ID NOs: 1, 3, 9, 15, 19, 31, 41, 43, 63, 65 and 67; a modified polypeptide having the amino acid sequence represented by SEQ ID NO: 67; and a method for determining an antibody titer or the presence of an antibody against a periodontal disease-causing bacterium in a blood sample separated from a human body, comprising bringing the blood sample into contact with the above-mentioned set of polypeptides.
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