发明公开
EP2658843A1 METHOD OF PREPARING POLYMORPHIC PURE FORM A OF BAZEDOXIFENE ACETATE
有权
一种用于生产多晶型PURE FORM A OFF醋酸巴多昔芬
- 专利标题： METHOD OF PREPARING POLYMORPHIC PURE FORM A OF BAZEDOXIFENE ACETATE
- 专利标题（中）： 一种用于生产多晶型PURE FORM A OFF醋酸巴多昔芬
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申请号： EP11802097.3申请日： 2011-12-21
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公开(公告)号： EP2658843A1公开(公告)日： 2013-11-06
- 发明人: PICHLER, Arthur , HOTTER, Andreas , LANGES, Christoph
- 申请人： Sandoz AG
- 申请人地址： Lichtstrasse 35 4056 Basel CH
- 专利权人： Sandoz AG
- 当前专利权人： Sandoz AG
- 当前专利权人地址： Lichtstrasse 35 4056 Basel CH
- 代理机构： Wichmann, Hendrik
- 优先权： EP10197175 20101228
- 国际公布： WO2012089593 20120705
- 主分类号： C07D209/12
- IPC分类号： C07D209/12 ; A61K31/404 ; A61K31/55 ; A61P19/10
摘要：
The present invention provides a reliable process for the preparation of polymorphic pure form A of Bazedoxifene x acetate. In addition, the present invention relates to a process of wet granulation of polymorphic pure form A of Bazedoxifene x acetate. The present invention also relates to pharmaceutical compositions comprising polymorphic pure form A of Bazedoxifene x acetate as well as to the use of cyclic ethers for the preparation of such pharmaceutical composition.
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