A method of operating an internal combustion engine is proposed, the engine comprising an exhaust system with a DOC and a DPF and, downstream thereof a SCR catalyst. The ECU is configured to allow operation in at least one of a normal mode and a heat-up mode. A predicted temperature evolution of said second exhaust after treatment means is regularly determined based on a thermal model taking into account the thermal inertia of the exhaust system and having as input the current temperatures of the DOC/DPF and SCR. The predicted temperature evolution of SCR is indicative of the temperature that the SCR may reach during a simulated time period in case the operating mode. The engine operating mode is changed depending on the predicted temperature evolution.