发明公开
- 专利标题： AMINO-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS
- 专利标题（中）： 氨基-3-丙酸衍生物杂芳及其作为药物
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申请号： EP12700866.2申请日： 2012-01-26
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公开(公告)号： EP2668167A1公开(公告)日： 2013-12-04
- 发明人: RUF, Sven , SADOWSKI, Thorsten , HORSTICK, Georg , SCHREUDER, Herman , BUNING, Christian , OLPP, Thomas , WIRTH, Klaus
- 申请人： SANOFI
- 申请人地址： 54, rue La Boétie 75008 Paris FR
- 专利权人： SANOFI
- 当前专利权人： SANOFI
- 当前专利权人地址： 54, rue La Boétie 75008 Paris FR
- 代理机构： Essler, Frank
- 优先权： EP11305077 20110126
- 国际公布： WO2012101199 20120802
- 主分类号： C07D231/14
- IPC分类号： C07D231/14 ; C07D275/03
摘要：
The present invention relates to compounds of the formula I, wherein A, D, E, G, R10, R11, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
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