发明公开
EP2673289A1 VIRAL VECTORS WITH MODIFIED TRANSDUCTION PROFILES AND METHODS OF MAKING AND USING THE SAME
审中-公开
与改进TRANSDUKTIONSPROFILEN和方法病毒载体的生产和使用
- 专利标题： VIRAL VECTORS WITH MODIFIED TRANSDUCTION PROFILES AND METHODS OF MAKING AND USING THE SAME
- 专利标题（中）： 与改进TRANSDUKTIONSPROFILEN和方法病毒载体的生产和使用
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申请号： EP12744695.3申请日： 2012-02-10
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公开(公告)号： EP2673289A1公开(公告)日： 2013-12-18
- 发明人: ASOKAN, Aravind , PULICHERLA, Nagesh
- 申请人： The University Of North Carolina At Chapel Hill
- 申请人地址： 308 Bynum Hall Campus Box 4105 Chapel Hill, NC 27599-4105 US
- 专利权人： The University Of North Carolina At Chapel Hill
- 当前专利权人： The University Of North Carolina At Chapel Hill
- 当前专利权人地址： 308 Bynum Hall Campus Box 4105 Chapel Hill, NC 27599-4105 US
- 代理机构： Ward, Siobhan
- 优先权： US201161441411P 20110210
- 国际公布： WO2012109570 20120816
- 主分类号： C07K14/075
- IPC分类号： C07K14/075 ; C12N15/861 ; A61P21/00 ; A61P9/00 ; A61P3/00
摘要：
The present invention provides AAV capsid proteins, virus capsids comprising said capsid proteins and virus vectors comprising said capsid proteins, wherein the AAV capsid proteins have one or more mutations, wherein the mutation(s) result in a phenotype of decreased liver transduction and/or reduced glycan binding affinity as compared to a control. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject.
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