发明公开
- 专利标题： MUTANT INTERLEUKIN-2 POLYPEPTIDES
- 专利标题（中）： 突变体白细胞介素-2多肽
-
申请号： EP12702045.1申请日： 2012-02-07
-
公开(公告)号： EP2673294A1公开(公告)日： 2013-12-18
- 发明人: AST, Oliver , BRUENKER, Peter , FREIMOSER-GRUNDSCHOBER, Anne , HERTER, Sylvia , HOFER, Thomas U. , HOSSE, Ralf , KLEIN, Christian , MOESSNER, Ekkehard , NICOLINI, Valeria G. , UMANA, Pablo
- 申请人： Roche Glycart AG
- 申请人地址： Wagistrasse 18 8952 Schlieren CH
- 专利权人： Roche Glycart AG
- 当前专利权人： Roche Glycart AG
- 当前专利权人地址： Wagistrasse 18 8952 Schlieren CH
- 代理机构： Küng, Peter
- 优先权： EP11153964 20110210; EP11164237 20110429
- 国际公布： WO2012107417 20120816
- 主分类号： C07K14/55
- IPC分类号： C07K14/55 ; C12N15/26 ; A61K39/395 ; A61K47/48
摘要：
The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the ±-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
公开/授权文献
- EP2673294B1 MUTANT INTERLEUKIN-2 POLYPEPTIDES 公开/授权日：2016-04-27
信息查询
