发明公开
- 专利标题： AMINO GROUP-CONTAINING PYRROLIDINONE DERIVATIVE
- 专利标题（中）： 氨基酸对苯二酚
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申请号： EP12744844.7申请日： 2012-02-06
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公开(公告)号： EP2674430A1公开(公告)日： 2013-12-18
- 发明人: INAGAKI, Hiroaki , FUJISAWA, Tetsunori , ITOH, Masao , YOKOMIZO, Aki , TSUDA, Toshifumi , HIGUCHI, Saito , DAS, Biswajit , KATOCH, Rita , UPADHYAY, Dilip, J.
- 申请人： Daiichi Sankyo Company, Limited
- 申请人地址： 3-5-1, Nihonbashi Honcho Chuo-ku Tokyo 103-8426 JP
- 专利权人： Daiichi Sankyo Company, Limited
- 当前专利权人： Daiichi Sankyo Company, Limited
- 当前专利权人地址： 3-5-1, Nihonbashi Honcho Chuo-ku Tokyo 103-8426 JP
- 代理机构： Nieuwenhuys, William Francis
- 优先权： JP2011023772 20110207; JP2011170823 20110804
- 国际公布： WO2012108376 20120816
- 主分类号： C07D413/14
- IPC分类号： C07D413/14 ; A61K31/538 ; A61K31/5383 ; A61P31/04 ; C07D471/04 ; C07D498/04 ; C07D519/00
摘要：
[Problems to be Solved by the Invention]
To provide a drug having excellent antibacterial activity against Gram-positive bacteria and Gram-negative bacteria and also being excellent in terms of safety.
[Means for Solving the Problems]
A compound represented by the following formula (I) or a salt thereof:
wherein R represents a hydrogen atom, a hydroxy group, or a halogen atom
m represents an integer 0, 1, or 2,
n represents an integer 0 or 1
Ar 1 represents a bicyclic heterocyclic group represented by the following formula:
wherein A a represents a nitrogen atom or C-R a , A b represents a nitrogen atom or C-R b , and A c represents a nitrogen atom or C-R c , R a , R b , and R c independently represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms,
R 1 and R 2 independently represent a hydrogen atom, an alkoxy group containing 1 to 6 carbon atoms, a halogenoalkoxy group containing 1 to 6 carbon atoms, a halogen atom, or a cyano group,
Ar 2 represents a bicyclic heterocyclic group represented by the following formulae:
To provide a drug having excellent antibacterial activity against Gram-positive bacteria and Gram-negative bacteria and also being excellent in terms of safety.
[Means for Solving the Problems]
A compound represented by the following formula (I) or a salt thereof:
wherein R represents a hydrogen atom, a hydroxy group, or a halogen atom
m represents an integer 0, 1, or 2,
n represents an integer 0 or 1
Ar 1 represents a bicyclic heterocyclic group represented by the following formula:
wherein A a represents a nitrogen atom or C-R a , A b represents a nitrogen atom or C-R b , and A c represents a nitrogen atom or C-R c , R a , R b , and R c independently represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms,
R 1 and R 2 independently represent a hydrogen atom, an alkoxy group containing 1 to 6 carbon atoms, a halogenoalkoxy group containing 1 to 6 carbon atoms, a halogen atom, or a cyano group,
Ar 2 represents a bicyclic heterocyclic group represented by the following formulae:
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