发明公开
EP2675807A1 6 - CYCLOBUTYL - 1, 5 - DIHYDRO - PYRAZOLO [3, 4-D]PYRIMIDIN- 4 - ONE DERIVATIVES THEIR USE AS PDE9A INHIBITORS
有权
6-环丁基-1,5-二氢吡唑并[3,4-d]嘧啶-4-酮及其作为PDE9抑制剂
- 专利标题： 6 - CYCLOBUTYL - 1, 5 - DIHYDRO - PYRAZOLO [3, 4-D]PYRIMIDIN- 4 - ONE DERIVATIVES THEIR USE AS PDE9A INHIBITORS
- 专利标题（中）： 6-环丁基-1,5-二氢吡唑并[3,4-d]嘧啶-4-酮及其作为PDE9抑制剂
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申请号： EP12705246.2申请日： 2012-02-13
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公开(公告)号： EP2675807A1公开(公告)日： 2013-12-25
- 发明人: HEINE, Niklas , GIOVANNINI, Riccardo , FERRARA, Marco
- 申请人： Boehringer Ingelheim International GmbH
- 申请人地址： Binger Strasse 173 55217 Ingelheim am Rhein DE
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： Binger Strasse 173 55217 Ingelheim am Rhein DE
- 代理机构： Simon, Elke Anna Maria
- 优先权： EP11154397 20110214; PCT/EP2011/063705 20110809
- 国际公布： WO2012110440 20120823
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/519 ; A61P25/28
摘要：
The invention relates to novel pyrazolopyrimidinones according to formula (I) wherein R1 is a pyridyl or pyrimidinyl group and D is optionally substituted cyclopentyl, cyclohexyl, tetrahydrofuranyl, tetrahydropyranyl or 2-, 3- or 4-pyridyl. The new compounds are for use as the active entity of medicaments or for the manufacture of medicaments respectively, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. Such conditions may for example be associated with Alzheimer's disease, schizophrenia and other diseases. The new compounds are also for example for the manufacture of medicaments and/or for use in the treatment of these diseases, in particular for cognitive impairment associated with such disease. The compounds of the invention show PDE9 inhibiting properties.
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