发明公开
EP2680864A1 GENETICALLY MODIFIED MUSCLE CELLS WHICH EXPRESS NEUROTROPHIC FACTORS
审中-公开
基因修饰肌肉与Expression因素神经营养
- 专利标题： GENETICALLY MODIFIED MUSCLE CELLS WHICH EXPRESS NEUROTROPHIC FACTORS
- 专利标题（中）： 基因修饰肌肉与Expression因素神经营养
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申请号： EP12711003.9申请日： 2012-03-01
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公开(公告)号： EP2680864A1公开(公告)日： 2014-01-08
- 发明人: OFFEN, Daniel , DADON-NACHUM, Michal , BEN-ZUR, Tali , MELAMED, Eldad , YAFFE, David
- 申请人： Ramot at Tel Aviv University, Ltd. , Yeda Research and Development Co. Ltd.
- 申请人地址： P.O. Box 39296 61392 Tel Aviv IL
- 专利权人： Ramot at Tel Aviv University, Ltd.,Yeda Research and Development Co. Ltd.
- 当前专利权人： Ramot at Tel Aviv University, Ltd.,Yeda Research and Development Co. Ltd.
- 当前专利权人地址： P.O. Box 39296 61392 Tel Aviv IL
- 代理机构： Peters, Hajo
- 优先权： US201161448712P 20110303
- 国际公布： WO2012117373 20120907
- 主分类号： A61K35/34
- IPC分类号： A61K35/34 ; C12N5/077 ; A61P25/00
摘要：
An isolated muscle progenitor cell being MyoD positive, CD34 negative and CD45 negative is disclosed. The muscle progenitor cell is genetically modified to express at least one neurotrophic factor. In addition, cell populations are disclosed, comprising at least four subpopulations of muscle cells each being genetically modified to express a different neurotrophic factor, wherein said neurotrophic factor is selected from the group consisting of glial derived neurotrophic factor (GDNF), insulin growth factor (IGF-1), vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF). Uses of the cell populations are also disclosed.
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