发明公开
- 专利标题： TCRALPHA/BETA-DEPLETIERTE ZELLPRÄPARATIONEN
- 专利标题（英）： Cell preparations depleted of tcr alpha/beta
- 专利标题（中）： TCRalpha / BETA耗尽细胞制剂
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申请号： EP12712611.8申请日： 2012-03-19
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公开(公告)号： EP2686417A1公开(公告)日： 2014-01-22
- 发明人: HANDGRETINGER, Rupert , HUPPERT, Volker
- 申请人： Miltenyi Biotec GmbH
- 申请人地址： Friedrich-Ebert-Strasse 68 51429 Bergisch Gladbach DE
- 专利权人： Miltenyi Biotec GmbH
- 当前专利权人： Miltenyi Biotec GmbH
- 当前专利权人地址： Friedrich-Ebert-Strasse 68 51429 Bergisch Gladbach DE
- 代理机构： Hoppe, Georg Johannes
- 优先权： DE102011001380 20110317; EP11168949 20110607
- 国际公布： WO2012123590 20120920
- 主分类号： C12N5/00
- IPC分类号： C12N5/00
摘要：
The invention relates to a composition, comprising a cell population that can be obtained from bone marrow or from blood, wherein the cell population is depleted of cells that express TCR alpha/beta and cells that express CD19. Such a pharmaceutical composition makes the reconstitution of the immune defense of a person as part of a bone marrow transplant possible. By means of the invention, the time until the immune reconstitution is considerably shortened and the immune responses after treatment are considerably reduced, in particular the occurrence of GVHD. The survival rate of the patients is considerably increased.
公开/授权文献
- EP2686417B1 TCRALPHA/BETA-DEPLETIERTE ZELLPRÄPARATIONEN 公开/授权日：2016-06-08
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