发明公开
- 专利标题： AZOLE COMPOUNDS AS PIM INHIBITORS
- 专利标题（中）： 吡咯化合物ALS抑制剂PIM
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申请号： EP12719496.7申请日： 2012-03-21
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公开(公告)号： EP2688886A1公开(公告)日： 2014-01-29
- 发明人: WANG, Hui-Ling , CEE, Victor, J. , HERBERICH, Bradley, J. , JACKSON, Claire, L., M. , LANMAN, Brian, Alan , NIXEY, Thomas , PETTUS, Liping, H. , REED, Anthony, B. , WU, Bin , WURZ, Ryan , TASKER, Andrew
- 申请人： Amgen Inc.
- 申请人地址： One Amgen Center Drive Thousand Oaks, CA 91320 US
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： One Amgen Center Drive Thousand Oaks, CA 91320 US
- 代理机构： HOFFMANN EITLE
- 优先权： US201161466410P 20110322
- 国际公布： WO2012129338 20120927
- 主分类号： C07D413/14
- IPC分类号： C07D413/14 ; C07D417/14 ; C07D417/04 ; C07D487/04 ; A61K31/496 ; A61K31/4439 ; A61K31/4745 ; A61K31/433 ; A61P35/00
摘要：
The invention relates to bicyclic compounds of formulas I and Ia, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
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