发明授权
EP2694112B1 ANTI-TUMOR ANTIBODY-TUMOR SUPPRESSOR FUSION PROTEIN COMPOSITIONS AND METHODS OF USE FOR THE TREATMENT OF CANCER
有权
抗肿瘤抗体 - 肿瘤抑制剂融合蛋白组合物及其用于治疗癌症的方法
- 专利标题： ANTI-TUMOR ANTIBODY-TUMOR SUPPRESSOR FUSION PROTEIN COMPOSITIONS AND METHODS OF USE FOR THE TREATMENT OF CANCER
- 专利标题（中）： 抗肿瘤抗体 - 肿瘤抑制剂融合蛋白组合物及其用于治疗癌症的方法
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申请号： EP12723769.1申请日： 2012-04-06
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公开(公告)号： EP2694112B1公开(公告)日： 2017-11-08
- 发明人: WENDEL, Hans-Guido , ORCCHIO, Elisa
- 申请人： Memorial Sloan-Kettering Cancer Center
- 申请人地址： 1275 York Avenue New York, NY 10065 US
- 专利权人： Memorial Sloan-Kettering Cancer Center
- 当前专利权人： Memorial Sloan-Kettering Cancer Center
- 当前专利权人地址： 1275 York Avenue New York, NY 10065 US
- 代理机构： Pearl Cohen Zedek Latzer Baratz UK LLP
- 优先权： US201161516738P 20110407
- 国际公布： WO2012139002 20121011
- 主分类号： C07K14/715
- IPC分类号： C07K14/715 ; C07K14/705 ; C07K16/28 ; C12N15/62 ; G01N33/574 ; A61K39/00
摘要：
The present invention is directed to methods and compositions for treating cancer, including, hematologic malignancies, such as B-cell malignancies, with anti-tumor antibody-tumor suppressor fusion proteins in order to selectively restore tumor suppressor gene function to cancer cells in which such tumor suppressor gene function has been lost. The present invention is also directed to methods and compositions for diagnosing cancer and for predicting and assessing response to treatment.
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