发明公开
- 专利标题: PHENYL PYRROLE DERIVATIVE CRYSTAL
- 专利标题(中): 苯基吡咯衍生物晶体
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申请号: EP12777084.0申请日: 2012-04-26
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公开(公告)号: EP2703400A1公开(公告)日: 2014-03-05
- 发明人: ONO, Makoto
- 申请人: Daiichi Sankyo Company, Limited
- 申请人地址: 3-5-1, Nihonbashi Honcho Chuo-ku Tokyo 103-8426 JP
- 专利权人: Daiichi Sankyo Company, Limited
- 当前专利权人: Daiichi Sankyo Company, Limited
- 当前专利权人地址: 3-5-1, Nihonbashi Honcho Chuo-ku Tokyo 103-8426 JP
- 代理机构: Fairbairn, Angus Chisholm
- 优先权: JP2011100162 20110427
- 国际公布: WO2012147832 20121101
- 主分类号: C07D413/14
- IPC分类号: C07D413/14 ; A61K31/497 ; A61P3/10
摘要:
Provided is a monomethanesulfonate of a phenylpyrrole derivative, having superior glucokinase activating activity and demonstrating remarkably improved solubility, hygroscopicity and stability as well as superior oral absorption, and crystals thereof. The present invention provides (2S)-2-(3-{5-[(5S)-5-methyl-4,5-dihydro-1,3-oxazol-2-yl]-1H-pyrrol-2-yl}-5-{[5-(methylsulfonyl)pyrazin-2-yl]oxy}phenoxy)propan-1-ol monomethanesulfonate having superior glucokinase activating activity, crystals thereof, a pharmaceutical containing the same, and a preventive and/or therapeutic agent for diabetes and the like.
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