发明公开
- 专利标题： AMINOMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES
- 专利标题（中）： 氨甲基二芳基苯并三唑衍生物
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申请号： EP12779437.8申请日： 2012-04-30
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公开(公告)号： EP2704573A1公开(公告)日： 2014-03-12
- 发明人: BESHORE, Douglas C. , GARBACCIO, Robert M. , KUDUK, Scott D. , JOHNSON, Adam W. , SKUDLAREK, Jason, W.
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US201161481821P 20110503
- 国际公布： WO2012151136 20121108
- 主分类号： A01N43/64
- IPC分类号： A01N43/64 ; A01N43/82 ; A61K31/41
摘要：
The present invention is directed to aminomethyl biaryl benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
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