发明公开
- 专利标题： [1,3]OXAZINES
- 专利标题（中）： [1,3]恶嗪
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申请号： EP12725747.5申请日： 2012-06-04
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公开(公告)号： EP2718287A1公开(公告)日： 2014-04-16
- 发明人: BORRONI, Edilio , GOBBI, Luca , HILPERT, Hans , HONER, Michael , MURI, Dieter , NARQUIZIAN, Robert , POLARA, Alessandra
- 申请人： F.Hoffmann-La Roche AG
- 申请人地址： Grenzacherstrasse 124 4070 Basel CH
- 专利权人： F.Hoffmann-La Roche AG
- 当前专利权人： F.Hoffmann-La Roche AG
- 当前专利权人地址： Grenzacherstrasse 124 4070 Basel CH
- 代理机构： Müller-Afraz, Simona
- 优先权： EP11168953 20110607
- 国际公布： WO2012168175 20121213
- 主分类号： C07D413/12
- IPC分类号： C07D413/12 ; A61K31/5355 ; A61P25/28
摘要：
The present invention provides compounds of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes. The invention further provides a radio-labelled derivative thereof.
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