发明公开
EP2734845A1 PRODUCTION AND USE OF BACTERIAL HISTAMINE
审中-公开
HERSTELLUNG UND VERWENDUNG VON BAKTERIELLEM HISTAMIN
- 专利标题： PRODUCTION AND USE OF BACTERIAL HISTAMINE
- 专利标题（中）： HERSTELLUNG UND VERWENDUNG VON BAKTERIELLEM HISTAMIN
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申请号： EP12738122.6申请日： 2012-07-20
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公开(公告)号： EP2734845A1公开(公告)日： 2014-05-28
- 发明人: VERSALOVIC, James , THOMAS, Carissa Michelle , CONNOLLY, Eamonn
- 申请人： Biogaia AB
- 申请人地址： Kungsbroplan 3A P.O. Box 3242 103 64 Stockholm SE
- 专利权人： Biogaia AB
- 当前专利权人： Biogaia AB
- 当前专利权人地址： Kungsbroplan 3A P.O. Box 3242 103 64 Stockholm SE
- 代理机构： Owen, Deborah Jane
- 优先权： US201161572742P 20110721; US201213552686 20120719
- 国际公布： WO2013011137 20130124
- 主分类号： G01N33/569
- IPC分类号： G01N33/569 ; A23L1/30 ; A61K35/74
摘要：
A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.
公开/授权文献
- EP2734845B1 PRODUCTION AND USE OF BACTERIAL HISTAMINE 公开/授权日：2018-08-29
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