发明公开
- 专利标题: 2-ACYLAMINOTHIAZOLE COMPOUND CRYSTALS
- 专利标题(中): 用2 ACYLAMINOTHIAZOL连接晶体
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申请号: EP12759833.2申请日: 2012-08-01
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公开(公告)号: EP2739621A1公开(公告)日: 2014-06-11
- 发明人: SUGASAWA, Keizo , MIYAFUJI, Akio , SUZUKI, Kenichi , AWAMURA, Yuji
- 申请人: Astellas Pharma Inc.
- 申请人地址: 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 103-8411 JP
- 专利权人: Astellas Pharma Inc.
- 当前专利权人: Astellas Pharma Inc.
- 当前专利权人地址: 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 103-8411 JP
- 代理机构: HOFFMANN EITLE
- 优先权: JP2011169730 20110803
- 国际公布: WO2013018362 20130207
- 主分类号: C07D417/14
- IPC分类号: C07D417/14 ; A61K31/496 ; A61P7/04
摘要:
The purpose of the present invention is to provide crystals of 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexyl piperazin-1-yl) thiazol-2-yl] carbamoyl} pyridin-2-yl) piperidine-4-carboxylic acid maleic acid salt that can ensure constant quality and constant effects as a drug substance for medicines, and that can be stably supplied in mass production such as industrial production. The present invention relates to crystals of 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexyl piperazin-1-yl) thiazol-2-yl] carbamoyl} pyridin-2-yl) piperidine-4-carboxylic acid maleic acid salt with endothermic peak top temperatures in differential scanning calorimeter analysis of between approximately 229 and 232 degree C, and between approximately 300 and 303 degree C. The crystals of the present invention are with excellent oral absorption, can be stably supplied in mass production such as industrial production or the like, and can be used as an active ingredient in a pharmaceutical composition for preventing and/or treating various types of thrombocytopenia.
公开/授权文献
- EP2739621B1 2-ACYLAMINOTHIAZOLE COMPOUND CRYSTALS 公开/授权日:2017-06-21
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