发明公开
EP2741770A1 ANTIBODIES BINDING TO PHOSPHORYLCHOLINE (PC) AND/OR PC CONJUGATES
审中-公开
抗体结合磷酰胆碱（PC）和/或PC结合物
- 专利标题： ANTIBODIES BINDING TO PHOSPHORYLCHOLINE (PC) AND/OR PC CONJUGATES
- 专利标题（中）： 抗体结合磷酰胆碱（PC）和/或PC结合物
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申请号： EP12821512.6申请日： 2012-08-08
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公开(公告)号： EP2741770A1公开(公告)日： 2014-06-18
- 发明人: PETTERSSON, Knut , CAMBER, Ola , SEXTON, Dan , NIXON, Andrew, E.
- 申请人： Athera Biotechnologies AB , Dyax Corp.
- 申请人地址： Fogdevreten 2A 171 77 Stockholm SE
- 专利权人： Athera Biotechnologies AB,Dyax Corp.
- 当前专利权人： Athera Biotechnologies AB,Dyax Corp.
- 当前专利权人地址： Fogdevreten 2A 171 77 Stockholm SE
- 代理机构： Potter Clarkson LLP
- 优先权： US201161521607P 20110809
- 国际公布： WO2013022968 20130214
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/395
摘要：
The present disclosure relates to an antibody or antibody fragment capable of binding to phosphorylcholine and/or a phosphorylcholine conjugate, wherein the antibody or antibody fragment comprises a variable heavy chain (VH) domain and/or a variable light chain (VL) domain, and wherein (a) the VH domain comprises complementarity determining regions (CDRs) selected from the group consisting of: a CDR1 sequence having identity to the sequence of SEQ ID NO: 7; a CDR2 sequence having identity to the sequence of SEQID NO: 8; and a CDR3 sequence having identity to the sequence of SEQ ID NO: 9 or 10; and/or (b) the VL domain comprises CDRs selected from the group consisting of: a CDR4 sequence having identity to the sequence of SEQ ID NO: 11; a CDR5 sequence having identity to the sequence of SEQ ID NO: 12; a CDR6 sequence having identity to the sequence of SEQ ID NO: 13.
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