发明公开
EP2741770A4 ANTIBODIES BINDING TO PHOSPHORYLCHOLINE (PC) AND/OR PC CONJUGATES
审中-公开
抗体与磷酸胆碱（PC）和/或PC偶联物结合
- 专利标题： ANTIBODIES BINDING TO PHOSPHORYLCHOLINE (PC) AND/OR PC CONJUGATES
- 专利标题（中）： 抗体与磷酸胆碱（PC）和/或PC偶联物结合
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申请号： EP12821512申请日： 2012-08-08
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公开(公告)号： EP2741770A4公开(公告)日： 2014-12-31
- 发明人: PETTERSSON KNUT , CAMBER OLA , SEXTON DAN , NIXON ANDREW E
- 申请人： ATHERA BIOTECHNOLOGIES AB , DYAX CORP
- 专利权人： ATHERA BIOTECHNOLOGIES AB,DYAX CORP
- 当前专利权人： ATHERA BIOTECHNOLOGIES AB,DYAX CORP
- 优先权： US201161521607 2011-08-09
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/395 ; C07K16/18 ; C07K16/44
摘要：
The present disclosure relates to an antibody or antibody fragment capable of binding to phosphorylcholine and/or a phosphorylcholine conjugate, wherein the antibody or antibody fragment comprises a variable heavy chain (VH) domain and/or a variable light chain (VL) domain, and wherein (a) the VH domain comprises complementarity determining regions (CDRs) selected from the group consisting of: a CDR1 sequence having identity to the sequence of SEQ ID NO: 7; a CDR2 sequence having identity to the sequence of SEQ ID NO: 8; and a CDR3 sequence having identity to the sequence of SEQ ID NO: 9 or 10; and/or (b) the VL domain comprises CDRs selected from the group consisting of: a CDR4 sequence having identity to the sequence of SEQ ID NO: 11; a CDR5 sequence having identity to the sequence of SEQ ID NO: 12; a CDR6 sequence having identity to the sequence of SEQ ID NO: 13.
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