发明公开
- 专利标题： ANTI-FZD10 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE
- 专利标题（中）： 单克隆抗体FZD10及使用方法
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申请号： EP12824632.9申请日： 2012-08-09
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公开(公告)号： EP2742067A2公开(公告)日： 2014-06-18
- 发明人: CUMMINGS, W., Jason , YABUKI, Munehisa , LEPPARD, John, Benjamin , WOOD, Christi, L. , MAIZELS, Nancy , ALLISON, Daniel, S. , TJOELKER, Larry, W.
- 申请人： Omeros Corporation
- 申请人地址： 1420 Fifth Avenue Suite 2600 Seattle, WA 98101 US
- 专利权人： Omeros Corporation
- 当前专利权人： Omeros Corporation
- 当前专利权人地址： 1420 Fifth Avenue Suite 2600 Seattle, WA 98101 US
- 代理机构： Cole, William Gwyn
- 优先权： US201161523102P 20110812; US201161548110P 20111017
- 国际公布： WO2013025446 20130221
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K39/395 ; A61P35/00
摘要：
The present invention relates generally to anti-FZD10 antibodies and to methods of using anti-FZD10 antibodies. In particular, the anti-FZD10 antibodies described herein are useful for altering one or more of survival, replication, differentiation and epithelial-to-mesenchymal cell transition of embryonic stem cells and/or for the treatment of diseases, such as a variety of cancers, associated with expression of FZD10, including as stand-alone therapies and in combination therapies with other agents.
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