发明授权
EP2746284B1 SALT AND POLYMORPH OF PYRAZOLOPYRIMIDINONE COMPOUND AND DRUG COMPOSITION, PREPARATION METHOD AND USE THEREOF
有权
盐和多晶型吡唑并嘧啶和活性物质，其制造方法相同，它们的用途
- 专利标题： SALT AND POLYMORPH OF PYRAZOLOPYRIMIDINONE COMPOUND AND DRUG COMPOSITION, PREPARATION METHOD AND USE THEREOF
- 专利标题（中）： 盐和多晶型吡唑并嘧啶和活性物质，其制造方法相同，它们的用途
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申请号： EP12823704.7申请日： 2012-08-14
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公开(公告)号： EP2746284B1公开(公告)日： 2017-04-12
- 发明人: LI, Jianfeng , TIAN, Guanghui , WANG, Zhen , SUO, Jin , JIANG, Xiangrui , LIU, Zheng , YANG, Xiaojun , XIE, Zhu , ZHAO, Xianguo , ZHU, Weiliang , JIANG, Hualiang , SHEN, Jingshan
- 申请人： Topharman Shanghai Co., Ltd. , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Topharman Shandong Co., Ltd.
- 申请人地址： 1088 Chuansha Road Pudong New District Shanghai 201209 CN
- 专利权人： Topharman Shanghai Co., Ltd.,Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Topharman Shandong Co., Ltd.
- 当前专利权人： Topharman Shanghai Co., Ltd.,Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Topharman Shandong Co., Ltd.
- 当前专利权人地址： 1088 Chuansha Road Pudong New District Shanghai 201209 CN
- 代理机构： Kador & Partner
- 优先权： CN201110236585 20110817
- 国际公布： WO2013023439 20130221
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/519 ; A61P15/10 ; A61P9/12 ; A61P15/00 ; A61P15/06 ; A61P13/08 ; A61P13/10 ; A61P13/00 ; A61P9/10 ; A61P9/04 ; A61P13/12 ; A61P29/00 ; A61P11/00 ; A61P11/06 ; A61P11/02 ; A61P37/08 ; A61P27/06 ; A61P1/00 ; A61P9/00 ; A61P25/00
摘要：
The present invention relates to new salts of pyrazolopyrimidinone represented by formula (I), and pharmaceutically acceptable polymorph, solvate, hydrate, dehydrate, co-crystallization, anhydrous, or amorphous form thereof, the pharmaceutical compositions, and a pharmaceutical unit dosage form containing the same, wherein x represents organic or inorganic acids, preferable maleic acid, succinic acid, methanesulfonic acid, hydrochloric acid, etc. The invention further relates to co-crystals or complexes of compounds of pyrazolopyrimidinone and pharmaceutical compositions containing the same. The present invention also relates to a process for the preparation, use thereof and pharmaceutical preparation containing the salts or crystalline forms.
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