发明公开
- 专利标题： COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS
- 专利标题（中）： 化合物和组合物C-KIT激酶抑制剂
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申请号： EP12762445.0申请日： 2012-08-29
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公开(公告)号： EP2751105A1公开(公告)日： 2014-07-09
- 发明人: LOREN, Jon , LI, Xiaolin , LIU, Xiaodong , MOLTENI, Valentina , NABAKKA, Juliet , NGUYEN, Bao , PETRASSI, Hank Michael James , YEH, Vince , RUCKER, Paul Vincent
- 申请人： IRM LLC
- 申请人地址： 131 Front Street P.O. Box HM 2899 Hamilton HM LX BM
- 专利权人： IRM LLC
- 当前专利权人： IRM LLC
- 当前专利权人地址： 131 Front Street P.O. Box HM 2899 Hamilton HM LX BM
- 代理机构： Marti, Christiane
- 优先权： US201161530046P 20110901
- 国际公布： WO2013033203 20130307
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437 ; A61P11/06
摘要：
The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRα, PDGFRβ) kinases.
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