发明公开
EP2753638A1 PROCESS FOR THE SYNTHESIS OF TELAVANCIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS AS WELL AS N-PROTECTED DERIVATIVES THEREOF
审中-公开
METHOD FOR特拉万星的合成及其盐和N-药学上可接受的保护的衍生物THEREOF
- 专利标题： PROCESS FOR THE SYNTHESIS OF TELAVANCIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS AS WELL AS N-PROTECTED DERIVATIVES THEREOF
- 专利标题（中）： METHOD FOR特拉万星的合成及其盐和N-药学上可接受的保护的衍生物THEREOF
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申请号： EP12759086.7申请日： 2012-09-07
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公开(公告)号： EP2753638A1公开(公告)日： 2014-07-16
- 发明人: BENITO-GARAGORRI, David
- 申请人： Sandoz AG
- 申请人地址： Lichtstrasse 35 4056 Basel CH
- 专利权人： Sandoz AG
- 当前专利权人： Sandoz AG
- 当前专利权人地址： Lichtstrasse 35 4056 Basel CH
- 代理机构： Wichmann, Hendrik
- 优先权： EP11180721 20110909
- 国际公布： WO2013034675 20130314
- 主分类号： C07K9/00
- IPC分类号： C07K9/00
摘要：
The invention relates to a process for the preparation of telavancin, or a pharmaceutically acceptable salt thereof, wherein said process comprises a reductive alkylation of vancomycin which provides N-protected-decylaminoethylvancomycin, followed by aminomethyiation to obtain N-protected-telavancin, which is then deprotected to provide telavancin, or a pharmaceutically acceptable salt thereof. Another embodiment refers to N-protected-telavancin and pharmaceutically acceptable salts thereof, which are formed during the process of the invention.
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