发明公开
- 专利标题： PYRROLOPYRIMIDINE AND PURINE DERIVATIVES
- 专利标题（中）： 吡咯和嘌呤衍生物
-
申请号： EP12780286.6申请日： 2012-09-10
-
公开(公告)号： EP2758402A1公开(公告)日： 2014-07-30
- 发明人: CHENG, Hengmiao , JOHNSON JR., Theodore Otto , KATH, John Charles , LIU, Kevin Kun-Chin , LUNNEY, Elizabeth Ann , NAGATA, Asako , NAIR, Sajiv Krishnan , PLANKEN, Simon Paul , SUTTON, Scott Channing
- 申请人： Pfizer Inc.
- 申请人地址： 235 East 42nd Street New York, NY 10017 US
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： 235 East 42nd Street New York, NY 10017 US
- 代理机构： Pfizer
- 优先权： US201161538103P 20110922; US201261639639P 20120427
- 国际公布： WO2013042006 20130328
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61P35/00 ; A61K31/519
摘要：
The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, T, V, W, X, Y, Z, ring A, R
1 , R
2 , R
3 , R
4 , R
5 , R
5a , R
6 , R
7 , R
8 , R
9 , R
10 , R
11 , R
12 , R
13 , R
14 , R
15 , R
16 , R
17 and m are defined herein. There novel pyrrolopyrimidine and purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
1 , R
2 , R
3 , R
4 , R
5 , R
5a , R
6 , R
7 , R
8 , R
9 , R
10 , R
11 , R
12 , R
13 , R
14 , R
15 , R
16 , R
17 and m are defined herein. There novel pyrrolopyrimidine and purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.
公开/授权文献
- EP2758402B9 PYRROLOPYRIMIDINE AND PURINE DERIVATIVES 公开/授权日：2016-09-14
信息查询
