An interconnect-power-manager (IPM) cooperates and communicates signals with an integrated-circuit-system-power-manager (SPM) in the integrated-circuit. The interconnect network (IN) is partitioned into multiple power domains and has hardware circuitry integrated into the IN to manage a quiescent state for all components in each power domain in the IN when a routing pathway for transactions in the IN spans across one or more power domain boundaries and causes interdependencies of power domains within the IN other than where the power domains of the initiator agent and final target agent of the transaction are located within. The SPM is configured to cooperate and communicate with the IPM to quiesce, to wake up, and any combination of the two, one or more of the multiple power domains within the IN.