发明授权
EP2759549B1 IL-31 monoclonal antibodies and methods of use
有权
IL-31-monoklonaleAntikörperund Verfahren zu deren Verwendung
- 专利标题： IL-31 monoclonal antibodies and methods of use
- 专利标题（中）： IL-31-monoklonaleAntikörperund Verfahren zu deren Verwendung
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申请号： EP14165476.4申请日： 2007-09-04
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公开(公告)号： EP2759549B1公开(公告)日： 2015-08-19
- 发明人: Siadak, Anthony W. , Bilsborough, Janine , Rene, Shirley
- 申请人： ZymoGenetics, Inc.
- 申请人地址： 1201 Eastlake Avenue East Seattle, WA 98102 US
- 专利权人： ZymoGenetics, Inc.
- 当前专利权人： ZymoGenetics, Inc.
- 当前专利权人地址： 1201 Eastlake Avenue East Seattle, WA 98102 US
- 代理机构： Griffin, Philippa Jane
- 优先权： US824403P 20060901; US890792P 20070220
- 主分类号： C07K16/24
- IPC分类号： C07K16/24 ; A61K39/395 ; C12N5/18 ; A61P37/00 ; A61P17/00
摘要：
There is provided an isolated monoclonal antibody or antigen-binding fragment thereof that competes with the monoclonal antibody produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation PTA-6815 for binding to a polypeptide consisting of amino acid residues 27-164 of SEQ ID NO:2; wherein the monoclonal antibody has a human IgG4 heavy chain immunoglobulin constant domain or wherein the antigen-binding fragment further comprises a human IgG4 heavy chain immunoglobulin constant domain; and wherein the monoclonal antibody or antigen-binding fragment inhibits signal transduction induced by the polypeptide through its heterodimeric receptor.
公开/授权文献
- EP2759549A3 IL-31 monoclonal antibodies and methods of use 公开/授权日：2014-08-27
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