发明公开
EP2760285A1 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF
有权
INDAZOLHEMMER中Wnt信号通路和疗效它们的应用
- 专利标题： INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF
- 专利标题（中）： INDAZOLHEMMER中Wnt信号通路和疗效它们的应用
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申请号： EP13772420.9申请日： 2013-03-13
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公开(公告)号： EP2760285A1公开(公告)日： 2014-08-06
- 发明人: HOOD, John , WALLACE, David, Mark , KC, Sunil, Kumar
- 申请人： Samumed, LLC
- 申请人地址： 9381 Judicial Drive Suite 160 San Diego, California 92121 US
- 专利权人： Samumed, LLC
- 当前专利权人： Samumed, LLC
- 当前专利权人地址： 9381 Judicial Drive Suite 160 San Diego, California 92121 US
- 代理机构： Duncan, Garreth Andrew
- 优先权： US201261620107P 20120404
- 国际公布： WO2013151708 20131010
- 主分类号： A01N43/54
- IPC分类号： A01N43/54
摘要：
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states. One embodiment disclosed herein includes a compound having the structure of Formula I:
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