发明公开
EP2761008A1 CHIMAERIC SURROGATE LIGHT CHAINS (SLC) COMPRISING HUMAN VPREB
审中-公开
嵌合替代轻链（SLC）与人的VpreB1
- 专利标题： CHIMAERIC SURROGATE LIGHT CHAINS (SLC) COMPRISING HUMAN VPREB
- 专利标题（中）： 嵌合替代轻链（SLC）与人的VpreB1
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申请号： EP12766714.5申请日： 2012-09-26
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公开(公告)号： EP2761008A1公开(公告)日： 2014-08-06
- 发明人: BRADLEY, Allan , LEE, E-Chiang , LIANG, Qi , SPENSBERGER, Dominik , ENGLAND, Nicholas
- 申请人： Kymab Limited
- 申请人地址： Meditrina (B260) Babraham Research Campus Cambridge, Cambridgeshire CB22 3AT GB
- 专利权人： Kymab Limited
- 当前专利权人： Kymab Limited
- 当前专利权人地址： Meditrina (B260) Babraham Research Campus Cambridge, Cambridgeshire CB22 3AT GB
- 代理机构： Hollywood, Jane Constance
- 优先权： GB201116495 20110926; GB201120423 20111128
- 国际公布： WO2013045916 20130404
- 主分类号： C12N15/85
- IPC分类号： C12N15/85 ; C12N5/10 ; C07K16/46
摘要：
The present invention relates inter alia to improvements in the production of chimaeric antibodies in non-human transgenic vertebrates such as mice and rats bearing one or more chimaeric antibody transgenes. In particular, the invention provides for improved non-human vertebrates and cells in which VpreB has been species-matched with the variable region of the chimaeric antibodies. Also, embodiments also provide for species-matching of the entire surrogate light chain for efficient pairing with chimaeric heavy chains during B-cell development in vivo in a non-human transgenic vertebrate setting.
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