发明公开
EP2768513A2 USE OF AVERMECTIN DERIVATIVE FOR INCREASING BIOAVAILABILITY AND EFFICACY OF MACROCYLIC LACTONES
审中-公开
USING A除虫菌素衍生物对增强大环内酯类生物利用度与效果
- 专利标题： USE OF AVERMECTIN DERIVATIVE FOR INCREASING BIOAVAILABILITY AND EFFICACY OF MACROCYLIC LACTONES
- 专利标题（中）： USING A除虫菌素衍生物对增强大环内酯类生物利用度与效果
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申请号： EP12783158.4申请日： 2012-10-18
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公开(公告)号： EP2768513A2公开(公告)日： 2014-08-27
- 发明人: LESPINE, Anne , PRICHARD, Roger , MENEZ, Cécile
- 申请人： Institut National de la Recherche Agronomique (INRA) , The Royal Institution for the Advancement of Learning / McGill University
- 申请人地址： 147, rue de l'Université 75338 Paris Cedex 07 FR
- 专利权人： Institut National de la Recherche Agronomique (INRA),The Royal Institution for the Advancement of Learning / McGill University
- 当前专利权人： Institut National de la Recherche Agronomique (INRA),The Royal Institution for the Advancement of Learning / McGill University
- 当前专利权人地址： 147, rue de l'Université 75338 Paris Cedex 07 FR
- 代理机构： Bourgouin, André
- 优先权： EP11306348 20111018
- 国际公布： WO2013057222 20130425
- 主分类号： A61K31/7048
- IPC分类号： A61K31/7048 ; A61P33/00 ; A61P35/00 ; A61P31/12 ; A61P25/08
摘要：
The present invention relates to the use of avermectin derivative as a drug for the treatment of parasitic infections. The avermectin derivative is represented by the formula (I) wherein: (i) R1 is chosen from the group constituted of —CH(CH3)2, —CH(CH3)CH2CH3, or cyclohexyle, (ii) X represents —CH2CH2—, or —CH═CH—, (iii) R2 is chosen from the group constituted of or —OH group, (iv) R3 is OH or NOH, (v) represents a single bond when R3 is OH, or a double bond when R3 is NOH, as an inhibitor of a membrane-bound protein which transports exogenous compounds out of target cells.
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