发明公开
- 专利标题： INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
- 专利标题（中）： 肾上腺延髓钾通道抑制剂
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申请号： EP12844606.9申请日： 2012-10-22
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公开(公告)号： EP2771005A1公开(公告)日： 2014-09-03
- 发明人: TANG, Haifeng , PIO, Barbara , TEUMELSAN, Nardos , PASTERNAK, Alexander , DEJESUS, Reynalda
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Hussain, Deeba
- 优先权： US201161550950P 20111025
- 国际公布： WO2013062892 20130502
- 主分类号： A61K31/4965
- IPC分类号： A61K31/4965 ; C07D241/08
摘要：
The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir 1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.
公开/授权文献
- EP2771005B1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL 公开/授权日：2016-05-18
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