This invention provides a system and method for aligning, feeding, trimming, slitting, rotating, cross-slitting and stacking sheets, each containing one or more discrete page images thereon that allows for greater automation of the overall process so that reduced or no manual intervention is required to generate completed book stacks or "blocks" from a stream or stack of printed sheets. Sheets are fed to a first, upstream trimming station (720) to remove margin edges and optionally separate the sheets relative to the discrete page images. The sheets are then rotated 90 degrees and fed to a second, downstream trimming station (3770, 4880, 4910) that trims the right-angle edges and optionally separates the sheets into a final group of full-bleed pages, removing margins and gutter strips.; The sheets are fed to a stacking assembly (780, 3790) to be stacked in page order and any rejected, defective sheets or stacks are removed from the order.