发明公开
- 专利标题： CATIONIC LIPID
- 专利标题（中）： 阳离子脂质
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申请号： EP12846224.9申请日： 2012-11-02
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公开(公告)号： EP2774912A1公开(公告)日： 2014-09-10
- 发明人: KUBOYAMA, Takeshi , ERA, Tomohiro , NAOI, Tomoyuki , YAGI, Nobuhiro
- 申请人： Kyowa Hakko Kirin Co., Ltd.
- 申请人地址： 1-6-1, Ohtemachi Chiyoda-ku Tokyo 100-8185 JP
- 专利权人： Kyowa Hakko Kirin Co., Ltd.
- 当前专利权人： Kyowa Hakko Kirin Co., Ltd.
- 当前专利权人地址： 1-6-1, Ohtemachi Chiyoda-ku Tokyo 100-8185 JP
- 代理机构： Vossius & Partner
- 优先权： US201161554622P 20111102; US201261670840P 20120712; US201261671341P 20120713
- 国际公布： WO2013065825 20130510
- 主分类号： C07C217/08
- IPC分类号： C07C217/08 ; A61K31/231 ; A61K31/24 ; A61K31/40 ; A61P29/00 ; A61P35/00 ; C07C219/08 ; C07C237/06 ; C07C271/20 ; C07D207/08 ; C07D207/12 ; C07D491/056 ; C12N15/09
摘要：
The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I)
(wherein: R 1 and R 2 are, the same or different, alkenyl, etc, and X 1 and X 2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and
X 3 is absent or is alkyl, etc,
Y is absent or anion,
a and b are, the same or different, 0 to 3, and
L 3 is a single bond, etc,
R 3 is alkyl, etc,
L 1 and L 2 are -O-, -CO-O- or -O-CO-),
a composition comprising the cationic lipid and a nucleic acid, and
a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.
(wherein: R 1 and R 2 are, the same or different, alkenyl, etc, and X 1 and X 2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and
X 3 is absent or is alkyl, etc,
Y is absent or anion,
a and b are, the same or different, 0 to 3, and
L 3 is a single bond, etc,
R 3 is alkyl, etc,
L 1 and L 2 are -O-, -CO-O- or -O-CO-),
a composition comprising the cationic lipid and a nucleic acid, and
a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.
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