发明公开
EP2780036A1 NANOPARTICLE COMPOSITIONS FOR GENERATION OF REGULATORY T CELLS AND TREATMENT OF AUTOIMMUNE DISEASES AND OTHER CHRONIC INFLAMMATORY CONDITIONS
有权
NANOTEILCHENZUSAMMENSETZUNGEN FOR GENERATING调节性T细胞和治疗自身免疫性疾病和其他慢性炎症疾病的
- 专利标题： NANOPARTICLE COMPOSITIONS FOR GENERATION OF REGULATORY T CELLS AND TREATMENT OF AUTOIMMUNE DISEASES AND OTHER CHRONIC INFLAMMATORY CONDITIONS
- 专利标题（中）： NANOTEILCHENZUSAMMENSETZUNGEN FOR GENERATING调节性T细胞和治疗自身免疫性疾病和其他慢性炎症疾病的
-
申请号： EP12790425.8申请日： 2012-11-14
-
公开(公告)号： EP2780036A1公开(公告)日： 2014-09-24
- 发明人: FREUND, Barbara , HEEREN, Jörg , NIELSEN, Peter , CARAMBIA, Antonella , HERKEL, Johannes , BRUNS, Oliver , LOHSE, Ansgar , LÜTH, Stefan , WELLER, Horst , SALMEN, Sunhild
- 申请人： Universitätsklinikum Hamburg-Eppendorf , Universität Hamburg , Heinrich-Pette-Institut Leibniz-Institut für experimentelle Virologie-Stiftung bürgerlichen Rechts -
- 申请人地址： Martinistrasse 52 20246 Hamburg DE
- 专利权人： Universitätsklinikum Hamburg-Eppendorf,Universität Hamburg,Heinrich-Pette-Institut Leibniz-Institut für experimentelle Virologie-Stiftung bürgerlichen Rechts -
- 当前专利权人： Universitätsklinikum Hamburg-Eppendorf,Universität Hamburg,Heinrich-Pette-Institut Leibniz-Institut für experimentelle Virologie-Stiftung bürgerlichen Rechts -
- 当前专利权人地址： Martinistrasse 52 20246 Hamburg DE
- 代理机构： UEXKÜLL & STOLBERG
- 优先权： EP11009032 20111114
- 国际公布： WO2013072051 20130523
- 主分类号： A61K39/39
- IPC分类号： A61K39/39 ; A61K47/48 ; A61K9/14 ; A61K9/51 ; A61K9/00 ; A61K9/107 ; A61K9/50
摘要：
The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core.
公开/授权文献
信息查询
