发明公开
EP2786998A1 THIENYL [3, 2-D]PYRIMIDIN-4-ONE COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF
有权
THIENYL [3，] 2-D PYRIMIDIN-4-ON-VERBINDUNGEN，HERSTELLUNGSVERFAHREN，PHARMAZEUTISCHE ZUSAMMENSETZUNGEN UND IHRE VERWENDUNG
- 专利标题： THIENYL [3, 2-D]PYRIMIDIN-4-ONE COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF
- 专利标题（中）： THIENYL [3，] 2-D PYRIMIDIN-4-ON-VERBINDUNGEN，HERSTELLUNGSVERFAHREN，PHARMAZEUTISCHE ZUSAMMENSETZUNGEN UND IHRE VERWENDUNG
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申请号： EP12853993.9申请日： 2012-10-23
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公开(公告)号： EP2786998A1公开(公告)日： 2014-10-08
- 发明人: LIU, Hong , LI, Jia , LI, Jian , LI, Jingya , WANG, Jiang , SU, Mingbo , LIAN, Jie , JIANG, Hualiang , CHEN, Kaixian
- 申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 申请人地址： 555 Zuchongzhi Road Zhangjiang, Pudong Shanghai 201203 CN
- 专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人地址： 555 Zuchongzhi Road Zhangjiang, Pudong Shanghai 201203 CN
- 代理机构： Von Kreisler Selting Werner - Partnerschaft von Patentanwälten und Rechtsanwälten mbB
- 优先权： CN201110393905 20111201; CN201210262331 20120726
- 国际公布： WO2013078765 20130606
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; A61K31/519 ; A61K31/55 ; A61P3/10
摘要：
Disclosed are new thienyl [3, 2-d] pyrimidin-4-one compounds shown as the general formula (I), preparation method, pharmaceutical compositions and pharmacological use thereof. The compounds are strong DPPIV (dipeptide peptidase IV) inhibitors and can treat type II diabetes through well inhibiting DPPIV indirectly increasing the content of GLP-1 in vivo and inducing a series of physiological actions in vivo. Therefore, the compounds could be developed as new promising drugs for treating diabetes.
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