发明公开
EP2793925A1 VARIANT ACTIVIN RECEPTOR POLYPEPTIDES, ALONE OR IN COMBINATION WITH CHEMOTHERAPY, AND USES THEREOF
审中-公开
ACTIVINREZEPTORPOLYPEPTIDVARIANTEN，单独或联合化疗及其用途
- 专利标题： VARIANT ACTIVIN RECEPTOR POLYPEPTIDES, ALONE OR IN COMBINATION WITH CHEMOTHERAPY, AND USES THEREOF
- 专利标题（中）： ACTIVINREZEPTORPOLYPEPTIDVARIANTEN，单独或联合化疗及其用途
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申请号： EP12809999.1申请日： 2012-12-19
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公开(公告)号： EP2793925A1公开(公告)日： 2014-10-29
- 发明人: SUN, Jeonghoon. , TAM, Lei-Ting Tony , HAN, Huiquan , KWAK, Keith Soo-Nyung , ZHOU, Xiaolan
- 申请人： Amgen Inc.
- 申请人地址： One Amgen Center Drive Thousand Oaks, California 91320 US
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： One Amgen Center Drive Thousand Oaks, California 91320 US
- 代理机构： Campbell, Patrick John Henry
- 优先权： US201113329897 20111219
- 国际公布： WO2013106175 20130718
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; A61K31/55 ; A61K45/06 ; C07K14/71 ; A61P35/00
摘要：
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
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