发明公开
- 专利标题： HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS
- 专利标题（中）： 杂环衍生物及其前列腺素D2受体调节剂
-
申请号： EP12823031.5申请日： 2012-12-20
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公开(公告)号： EP2794563A1公开(公告)日： 2014-10-29
- 发明人: AISSAOUI, Hamed , BOSS, Christoph , RICHARD-BILDSTEIN, Sylvia , SIEGRIST, Romain
- 申请人： Actelion Pharmaceuticals Ltd.
- 申请人地址： Gewerbestrasse 16 4123 Allschwil CH
- 专利权人： Actelion Pharmaceuticals Ltd.
- 当前专利权人： Actelion Pharmaceuticals Ltd.
- 当前专利权人地址： Gewerbestrasse 16 4123 Allschwil CH
- 代理机构： Koberstein, Ralf
- 优先权： PCT/IB2011/055866 20111221
- 国际公布： WO2013093842 20130627
- 主分类号： C07D209/44
- IPC分类号： C07D209/44 ; C07D217/06 ; C07D223/06 ; C07D223/16 ; C07D401/06 ; C07D401/12 ; C07D405/06 ; C07D413/06 ; C07D417/06 ; A61K31/47
摘要：
The present invention relates to phenyl-substituted heterocyclyl derivatives of the formula (I) wherein Z, n, m, R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 and R
8 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D
2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 and R
8 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D
2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
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