发明公开
EP2796557A1 Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal for increasing the expression of an encoded protein
审中-公开
核酸与或为编码组蛋白茎 - 环结构，和聚（A）序列或用于增加编码的蛋白的表达的多腺苷酸化信号
- 专利标题： Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal for increasing the expression of an encoded protein
- 专利标题（中）： 核酸与或为编码组蛋白茎 - 环结构，和聚（A）序列或用于增加编码的蛋白的表达的多腺苷酸化信号
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申请号： EP14002182.5申请日： 2011-08-12
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公开(公告)号： EP2796557A1公开(公告)日： 2014-10-29
- 发明人: Theß, Andreas , Schlake, Thomas , Probst, Jochen
- 申请人： CureVac GmbH
- 申请人地址： Paul-Ehrlich-Strasse 15 72076 Tübingen DE
- 专利权人： CureVac GmbH
- 当前专利权人： CureVac GmbH
- 当前专利权人地址： Paul-Ehrlich-Strasse 15 72076 Tübingen DE
- 代理机构： Graf von Stosch, Andreas
- 优先权： PCT/EP2010/004998 20100813
- 主分类号： C12N15/67
- IPC分类号： C12N15/67
摘要：
The present application describes a coding nucleic acid sequence, particularly a messenger RNA (mRNA), comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal and the use thereof for increasing the expression of an encoded protein. It also discloses its use for the preparation of a pharmaceutical composition, especially a vaccine e.g. for the use in the treatment of tumours and cancer diseases, cardiovascular diseases, infectious diseases, autoimmune diseases or genetic diseases, or in gene therapy. The present invention further describes an in vitro transcription method, in vitro methods for increasing the expression of a protein using the nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal and an ex vivo and in vivo method.
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