发明公开
EP2797597A1 SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION
审中-公开
取代HETEROARYLALDEHYDVERBINDUNGEN和方法用于组织氧合的增加
- 专利标题： SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION
- 专利标题（中）： 取代HETEROARYLALDEHYDVERBINDUNGEN和方法用于组织氧合的增加
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申请号： EP12862096.0申请日： 2012-12-28
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公开(公告)号： EP2797597A1公开(公告)日： 2014-11-05
- 发明人: METCALF, Brian , CHUANG, Chihyuan , WARRINGTON, Jeffrey , PAULVANNAN, Kumar , JACOBSON, Matthew P. , HUA, Lan , MORGAN, Bradley
- 申请人： Global Blood Therapeutics, Inc. , Cytokinetics, Inc. , The Regents of the University of California
- 申请人地址： 29 Newbury Street Boston, Massachusetts 02116 US
- 专利权人： Global Blood Therapeutics, Inc.,Cytokinetics, Inc.,The Regents of the University of California
- 当前专利权人： Global Blood Therapeutics, Inc.,Cytokinetics, Inc.,The Regents of the University of California
- 当前专利权人地址： 29 Newbury Street Boston, Massachusetts 02116 US
- 代理机构： Campbell, Patrick John Henry
- 优先权： US201161581063P 20111228; US201261661327P 20120618
- 国际公布： WO2013102145 20130704
- 主分类号： A61K31/44
- IPC分类号： A61K31/44
摘要：
Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
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