发明公开
EP2799546A1 RADIATION EXPOSURE DIAGNOSTIC MARKER IGFBP-5, COMPOSITION FOR RADIATION EXPOSURE DIAGNOSIS BY MEASURING THE EXPRESSION LEVEL OF THE MARKER, RADIATION EXPOSURE DIAGNOSTIC KIT COMPRISING THE COMPOSITION, AND METHOD FOR DIAGNOSING RADIATION EXPOSURE USING THE MARKER
有权
曝光诊断标记物IGFBP-5 AND METHOD FOR诊断辐射暴露的BY测量标记的表达水平的
- 专利标题： RADIATION EXPOSURE DIAGNOSTIC MARKER IGFBP-5, COMPOSITION FOR RADIATION EXPOSURE DIAGNOSIS BY MEASURING THE EXPRESSION LEVEL OF THE MARKER, RADIATION EXPOSURE DIAGNOSTIC KIT COMPRISING THE COMPOSITION, AND METHOD FOR DIAGNOSING RADIATION EXPOSURE USING THE MARKER
- 专利标题（中）： 曝光诊断标记物IGFBP-5 AND METHOD FOR诊断辐射暴露的BY测量标记的表达水平的
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申请号： EP12862230.5申请日： 2012-05-09
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公开(公告)号： EP2799546A1公开(公告)日： 2014-11-05
- 发明人: KIM, Kwang Seok , BAE, Sang Woo , CHOI, Kyu Jin , KIM, Eun Sook
- 申请人： Korea Institute of Radiological & Medical Sciences
- 申请人地址： 215-4 Gongneung-dong Nowon-gu, Seoul 139-240 KR
- 专利权人： Korea Institute of Radiological & Medical Sciences
- 当前专利权人： Korea Institute of Radiological & Medical Sciences
- 当前专利权人地址： 215-4 Gongneung-dong Nowon-gu, Seoul 139-240 KR
- 代理机构： Potter Clarkson LLP
- 优先权： KR20110147425 20111230
- 国际公布： WO2013100273 20130704
- 主分类号： C12N15/11
- IPC分类号： C12N15/11 ; G01N33/53 ; G01N33/68 ; C12Q1/68
摘要：
The present invention provides: a composition for radiation exposure diagnosis including an agent for measuring an expression level of an insulin-like growth factor-binding protein-5 (IGFBP-5) gene at an mRNA or the protein; a kit for radiation exposure diagnosis including the composition; a method of diagnosing radiation exposure by measuring the expression level of the IGFBP-5 gene at an mRNA or the protein in a patient's sample; a method of screening an agent for enhancing radiation sensitivity by selecting a sample having increased expression levels of the IGFBP-5 gene at an mRNA or the protein compared to those of a control group; a method of screening an agent for radiation protection by selecting a sample having decreased expression levels of the IGFBP-5 gene at an mRNA or the protein compared to those of a control group; a composition for enhancing radiation sensitivity including an agonist to expression or action of the IGFBP-5 gene at an mRNA or the protein; and a composition for radiation protection including an antagonist to expression or action of the IGFBP-5 gene at an mRNA or the protein.
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