发明公开
- 专利标题： SIGNATURE FOR THE DIAGNOSIS OF LUNG CANCER AGGRESSIVENESS AND GENETIC INSTABILITY
- 专利标题（中）： 签名诊断癌症的侵略性
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申请号： EP13700490.9申请日： 2013-01-07
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公开(公告)号： EP2800821A1公开(公告)日： 2014-11-12
- 发明人: CAZAUX, Christophe , HOFFMANN, Jean-Sébastien
- 申请人： Centre National de la Recherche Scientifique (CNRS)
- 申请人地址： 3, rue Michel-Ange 75016 Paris FR
- 专利权人： Centre National de la Recherche Scientifique (CNRS)
- 当前专利权人： Centre National de la Recherche Scientifique (CNRS)
- 当前专利权人地址： 3, rue Michel-Ange 75016 Paris FR
- 代理机构： Regimbeau
- 优先权： EP12305012 20120105
- 国际公布： WO2013102680 20130711
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
The present invention relates to a method for diagnosing aggressiveness of a lung cancer in a patient from a lung cancer sample of the patient, comprising: a) detecting in vitro an expression profile of the DNA replication stress signature, the signature comprising the CDC6, CLASPIN, PLK1, and POLQ genes, as well as, optionally, RAD51; b) comparing the the expression profile to a reference expression profile, and d) diagnosing cancer aggressiveness from the comparison. Dedicated microarrays and kits are also described, as well as a method of selecting or adapting a suitable treatment.
公开/授权文献
- EP2800821B1 SIGNATURE FOR THE DIAGNOSIS OF LUNG CANCER AGGRESSIVENESS 公开/授权日：2016-11-16
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