发明公开
EP2814963A1 NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED THERAPEUTIC PROTEIN
审中-公开
以有或编码组蛋白的发夹结构和聚（A）序列或聚腺苷酸化CODED信号的治疗性蛋白NUCLEIC
- 专利标题： NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED THERAPEUTIC PROTEIN
- 专利标题（中）： 以有或编码组蛋白的发夹结构和聚（A）序列或聚腺苷酸化CODED信号的治疗性蛋白NUCLEIC
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申请号： EP13704552.2申请日： 2013-02-15
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公开(公告)号： EP2814963A1公开(公告)日： 2014-12-24
- 发明人: THESS, Andreas , SCHLAKE, Thomas , PROBST, Jochen
- 申请人： Curevac GmbH
- 申请人地址： Paul-Ehrlich-Str. 15 72076 Tübingen DE
- 专利权人： Curevac GmbH
- 当前专利权人： Curevac GmbH
- 当前专利权人地址： Paul-Ehrlich-Str. 15 72076 Tübingen DE
- 代理机构： Graf von Stosch, Andreas
- 优先权： PCT/EP2012/000671 20120215
- 国际公布： WO2013120629 20130822
- 主分类号： C12N15/68
- IPC分类号： C12N15/68 ; A61K39/00 ; A61K39/35 ; C12N15/117
摘要：
The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a therapeutic protein or a fragment, variant or derivative thereof, at least one histone stem-loop and a poly(A) sequence or a polyadenylation signal. Furthermore the present invention provides the use of the nucleic acid for increasing the expression of said encoded peptide or protein, particularly for the use in gene therapy. It also discloses its use for the preparation of a pharmaceutical composition, e.g. for use in gene therapy, particularly in the treatment of diseases which are in need of a treatment with a therapeutic peptide or protein, preferably as defined herein. The present invention further describes a method for increasing the expression of a peptide or protein comprising a therapeutic protein or a fragment, variant or derivative thereof, using the nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal.
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