发明公开
EP2818476A1 METHOD FOR PREPARING 3-O-BENZYL-1,2-O-ISOPROPYLIDENE- -L-FURAN IDOSE
审中-公开
用于生产3-O-苄基1,2-O-异亚丙基-L- FURANIDOSE
- 专利标题： METHOD FOR PREPARING 3-O-BENZYL-1,2-O-ISOPROPYLIDENE- -L-FURAN IDOSE
- 专利标题（中）： 用于生产3-O-苄基1,2-O-异亚丙基-L- FURANIDOSE
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申请号： EP13751650.6申请日： 2013-02-22
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公开(公告)号： EP2818476A1公开(公告)日： 2014-12-31
- 发明人: GUO, Yanghui , WEI, Hegeng , ZHOU, Junhui , WU, Yingqiu , ZHANG, Yue , BAI, Hua , HE, Liang , DING, Yili
- 申请人： Zhejiang Hisun Pharmaceutical Co. Ltd.
- 申请人地址： No. 46 Waisha Road Jiaojiang District Taizhou Zhejiang 318000 CN
- 专利权人： Zhejiang Hisun Pharmaceutical Co. Ltd.
- 当前专利权人： Zhejiang Hisun Pharmaceutical Co. Ltd.
- 当前专利权人地址： No. 46 Waisha Road Jiaojiang District Taizhou Zhejiang 318000 CN
- 代理机构： Kador & Partner
- 优先权： CN201210050766 20120223
- 国际公布： WO2013123896 20130829
- 主分类号： C07H15/18
- IPC分类号： C07H15/18 ; C07H15/26 ; C07H15/00 ; C07H9/00 ; C07H9/02 ; C07H9/04 ; C07D493/00 ; C07D493/02 ; C07D493/04
摘要：
Provided is a method for preparing 3-O-benzyl-1,2-O-isopropylidene-α-L-idofuranose, which comprises: (1) protecting hydroxyl of 3-O-benzyl-1,2-O-isopropylidene-α-D-glucofuranose (III) by benzoyl and methylsulfonyl to obtain 6-O-benzoyl-3-O-benzyl-1,2-O-isopropylidene-5-O-methylsulfonyl-α-D-glucofuranose (V); (2) subjecting compound (V) to a cyclization reaction under an alkaline condition to obtain 5,6-epoxy-3-O-benzyl-1,2-O-isopropylidene-α-L-idofuranose (VI); and (3) subjecting compound (VI) to a ring-opening reaction to obtain 3-O-benzyl-1,2-O-isopropylidene-α-L-idofuranose.
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