发明授权
- 专利标题: LONG LIFE POLYPEPTIDE BINDING MOLECULES
- 专利标题(中): 长寿多肽结合分子
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申请号: EP13716734.2申请日: 2013-03-01
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公开(公告)号: EP2820047B1公开(公告)日: 2018-04-25
- 发明人: KUFER, Peter , RAUM, Tobias , LUTTERBUESE, Ralf , HOFFMANN, Patrick , MUENZ, Markus , BROZY, Johannes , KVESIC, Majk
- 申请人: Amgen Research (Munich) GmbH
- 申请人地址: Staffelseestrasse 2 81477 München DE
- 专利权人: Amgen Research (Munich) GmbH
- 当前专利权人: Amgen Research (Munich) GmbH
- 当前专利权人地址: Staffelseestrasse 2 81477 München DE
- 代理机构: Schiweck, Weinzierl & Koch Patentanwälte Partnerschaft mbB
- 优先权: US201261605681P 20120301; US201261606268P 20120302
- 国际公布: WO2013128027 20130906
- 主分类号: C07K16/28
- IPC分类号: C07K16/28
摘要:
The present invention relates to a binding molecule comprising at least three domains comprised in at least one polypeptide chain, wherein the first binding domain is a binding domain which is capable of binding to a cell surface molecule on a target cell, the second binding domain is a binding domain which is capable of binding to the T cell CD3 receptor complex, and the third domain is a binding domain which is capable of binding to serum albumin, wherein said third domain is positioned at the C-terminus of said second domain. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
公开/授权文献
- EP2820047A1 LONG LIFE POLYPEPTIDE BINDING MOLECULES 公开/授权日:2015-01-07
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