A needle retractable-type safe self-destructing syringe, which comprises a barrel body (1). A needle base body (3) is arranged within a barrel neck of an end part of the barrel body (1). The barrel neck (2) and the needle base body (3) form therebetween a flexible cushioning stopper mechanism (4). An asymmetric retracting-locking piece (10) having a flexibility feature is arranged at an end part of a syringe plunger (8). The flexibility feature implements engaging and locking with an outer sleeve-type retracting-locking component (5) at the lower part of the needle base body (3). In a stress environment of an asymmetric force, the needle base body (3) deflects to a side after being retracted into the barrel body (1), while an injection needle therefore swings in the direction of a nearly 45 degree angle to a side of the inner wall of the barrel body (1) and is locked by a neck part (2). This effectively prevents secondary injury caused by the needle being pushed out, and implements truly safe self-destruction of the syringe. The flexible asymmetric retracting-locking piece (10) is a plastic barb body; same is formed with the plunger (8) in a single mold-forming.