发明公开
EP2822928A4 SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS
审中-公开
替代性杂环化合物乙酰胺ALA KAPPA-OPIATREZEPTOR（KOR）-AGONISTEN
- 专利标题： SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS
- 专利标题（中）： 替代性杂环化合物乙酰胺ALA KAPPA-OPIATREZEPTOR（KOR）-AGONISTEN
-
申请号： EP13757759申请日： 2013-03-05
-
公开(公告)号： EP2822928A4公开(公告)日： 2015-08-05
- 发明人: SASMAL PRADIP KUMAR , VAMSEEKRISHNA CHINTAKUNTA , POTLURI VIJAY , TEHIM ASHOK , GAI YONGHUA , ZHANG HANG
- 申请人： REDDYS LAB LTD DR
- 专利权人： REDDYS LAB LTD DR
- 当前专利权人： REDDYS LAB LTD DR
- 优先权： US201261606632 2012-03-05
- 主分类号： C07D207/04
- IPC分类号： C07D207/04 ; C07D209/34 ; C07D215/227 ; C07D217/12 ; C07D263/58 ; C07D265/36 ; C07D275/06 ; C07D277/68 ; C07D279/16 ; C07D401/12 ; C07D403/12 ; C07D403/14 ; C07D413/12 ; C07D413/14 ; C07D417/12 ; C07D417/14
摘要：
The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, and R6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (&kgr;) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.
信息查询
