发明公开
EP2822942A1 BENZODIOXANES FOR INHIBITING LEUKOTRIENE PRODUCTION
有权
BENZODIOXANE ZUR HEMMUNG DER LEUKOTRIENPRODUKTION
- 专利标题： BENZODIOXANES FOR INHIBITING LEUKOTRIENE PRODUCTION
- 专利标题（中）： BENZODIOXANE ZUR HEMMUNG DER LEUKOTRIENPRODUKTION
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申请号： EP13712002.8申请日： 2013-03-05
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公开(公告)号： EP2822942A1公开(公告)日： 2015-01-14
- 发明人: BRUNETTE, Steven, Richard , ABEYWARDANE, Asitha , BURKE, Michael, J. , KAPADIA, Suresh, R. , KIRRANE, Thomas, Martin, Jr. , NETHERTON, Matthew, Russell , RAZAVI, Hossein , RODRIGUEZ, Sonia , SAHA, Anjan , SIBLAY, Robert , SMITH KEENAN, Lana, Louise , TAKAHASHI, Hidenori , TURNER, Michael, Robert , WU, Jiang-Ping , YOUNG, Erick, Richard, Roush , ZHANG, Qiang , ZHANG, Qing , ZINDELL, Renee, M.
- 申请人： Boehringer Ingelheim International GmbH
- 申请人地址： Binger Strasse 173 55216 Ingelheim DE
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： Binger Strasse 173 55216 Ingelheim DE
- 代理机构： Simon, Elke Anna Maria
- 优先权： US201261607136P 20120306
- 国际公布： WO2013134226 20130912
- 主分类号： C07D405/14
- IPC分类号： C07D405/14 ; A61K31/357 ; C07D319/20 ; C07D405/10 ; C07D405/12 ; C07D487/10 ; A61P9/00
摘要：
The present invention relates to compounds of formula (I) wherein R
1 to R
3 , A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A
4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
1 to R
3 , A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A
4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
公开/授权文献
- EP2822942B1 BENZODIOXANES FOR INHIBITING LEUKOTRIENE PRODUCTION 公开/授权日：2017-05-10
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